Chemical Synthesis of Glycosphingolipids

Characterization of glycosphingolipids by direct inlet chemical ionization mass spectrometry.

Permethylated derivatives of cerebrosides and ceramide di-, tri-, tetra-, and penta-hexosides were analyzed by the direct inlet ammonia chemical ionization (CI) mass spectrometry. In the CI mass spectra, the fragment ions produced by the loss of methanol from the protonated molecular ion were observed in all of the glycosphingolipids. Other fragment ions due to the cleavage of glycosidic moiety...

Synthesis of Complex Glycosphingolipids of the Globo Series

Versatile strategies were designed for the synthesis of biologically important glycosphingolipids of the globo series, as illustrated for the synthesis of the hexasaccharide of the human breast cancer antigen (Globo H, MBr1) and of the stage-specific embryonic antigen 4 (SSEA-4, Sialylgalactosylgloboside).

Glycosylation of Amino Acids and Efficient Synthesis of Glycosphingolipids

Glycoscience is an emerging field of science that focuses on the study of the structure, biosynthesis, biology, and evolution of saccharides (sugars). It covers a broad range of subjects including microwave-assisted synthesis as well as sphingolipid synthesis. In this field, knowledge is limited due to the complexity of carbohydrates and their derivatives. Therefore, it is all the more importan...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

synthesis of platinum nanostructures in two phase system

چکیده پلاتین، فلزی نجیب، پایدار و گران قیمت با خاصیت کاتالیزوری زیاد است که کاربرد های صنعتی فراوانی دارد. کمپلکس های پلاتین(ii) به عنوان دارو های ضد سرطان شناخته شدند و در شیمی درمانی بیماران سرطانی کاربرد دارند. خاصیت کاتالیزوری و عملکرد گزینشی پلاتین مستقیماً به اندازه و- شکل ماده ی پلاتینی بستگی دارد. بعضی از نانو ذرات فلزی در سطح مشترک مایع- مایع سنتز شده اند، اما نانو ساختار های پلاتین ب...